Simvastatin acid ammonium

SKU: orb1706632

Description

Simvastatin acid ammonium (Tenivastatin ammonium) is a competitive HMG-CoA reductase inhibitor that blocks cholesterol biosynthesis. It is widely used in biochemical research to study lipid metabolism and evaluate hypolipidemic effects in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 139893-43-9
• MW: 453.61
• Purity: 99.79% (May vary between batches)
• Formula: C₂₅H₄₃NO₆
• SMILES: CCC(C)(C)C(O[C@@H]1[C@@]2([H])C(C=C[C@@H]([C@@H]2CC[C@@H](O)C[C@@H](O)CC([O-])=O)C)=C[C@@H](C1)C)=O.[NH4+]
• Target: HMG-CoA Reductase,ROS,Reactive Oxygen Species
• Solubility: DMSO:4 mg/mL (8.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.2 mM)

Bioactivity

• In Vitro:
  Simvastatin acid ammonium (0.1-20 μM, treated for 24 h) significantly inhibited ROS production in indolephenol sulfate-treated hCM cells, with reductions ranging from 8.9% to 43%. In addition, 0.1-20 μM Simvastatin acid ammonium, treated for 24 hours, also affected the expression level of OATP3A1 protein in hCM and OATP3A1-expressing HEK293 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tenivastatin ammonium, Simvastatin acid ammonium, Human Endogenous Metabolite

Compound Identifiers

PubChem CID

10961424