SIM010603

SKU: orb1737904

Description

SIM010603 is an orally bioavailable, multi-targeted tyrosine kinase inhibitor that potently inhibits KIT, VEGFR-2, PDGFR-β, RET, and FLT3. It blocks receptor phosphorylation and has demonstrated anti-angiogenic effects in cellular assays, including inhibition of endothelial cell proliferation and migration, supporting its research use in oncology and angiogenesis studies.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1032265-67-0
• MW: 396.46
• Formula: C₂₂H₂₅FN₄O₂
• SMILES: O=C1/C(=C/2\C3=C(C(C(NCCN(C)C)=O)=C(C)N3)CCC2)/C=4C(N1)=CC=C(F)C4
• Target: c-RET,Others,VEGFR,c-Kit

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

59376014