SILA-123

SKU: orb2665145

Description

SILA-123 is a potent and selective FLT3 inhibitor (IC50=2.1 nM for FLT3-WT, 1.0 nM for FLT3-ITD) used in acute myeloid leukemia research. It induces apoptosis and G0/G1 cell cycle arrest by blocking FLT3 phosphorylation and downstream signaling, as demonstrated in cellular studies.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2911585-37-8
• MW: 415.49
• Formula: C₂₄H₂₅N₅O₂
• SMILES: O=C(NC=1C=CC(=CC1)C=2C=C(N=C3ON=C(N)C32)C)NC4=CC=C(C=C4)C(C)(C)C
• Target: Apoptosis,FLT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172652586