SIK2/3-IN-2

SKU: orb3174891

Description

SIK2/3-IN-2 (compound 12, compound I-200) is a potent SIK2/3 inhibitor, with IC50 values of 65 nM for SIK2 and 14 nM for SIK3. It also acts as an inhibitor of p21-activated kinase (PAK)1, with a Ki of 20.7 nM. SIK2/3-IN-2 is applicable in research on proliferative diseases and cancer, such as paclitaxel-resistant ovarian cancer.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1648864-21-4
• MW: 492.96
• Formula: C₂₅H₂₅ClN₆O₃
• SMILES: C(N1C=2C(C=C(C1=O)C3=C(Cl)C=C(C=C3)C4=C(C)C=CC=N4)=CN=C(NC)N2)[C@H]5OC[C@H](N)CO5
• Target: SIK,PAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

SIK,PAK