Sigma-LIGAND-1

SKU: orb1708084

Description

Sigma-LIGAND-1 is a selective sigma receptor ligand exhibiting high affinity at the DTG and PPP binding sites, with IC50 values of 16 nM and 19 nM, respectively. It shows significantly lower affinity for the dopamine D2 receptor (Ki = 4000 nM). This profile makes it a useful research tool for investigating sigma receptor function in neuropharmacological studies, both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 139652-01-0
• MW: 435.56
• Purity: 99.89% (May vary between batches)
• Formula: C₂₇H₃₃NO₄
• SMILES: Cc1c(oc2ccc(OCCCCCCN3CCC(O)CC3)cc2c1=O)-c1ccccc1
• Target: Sigma receptor
• Solubility: DMSO:90 mg/mL (206.63 mM)

Bioactivity

• Target IC50:
  DTG site of sigma receptor:16 nM |σ receptor (PPP site):19 nM
• In Vivo:
  Sigma-LIGAND-1 administration reverses amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DTG site of sigma receptor, PPP site of sigma receptor, Sigma LIGAND 1, Sigma receptor, SigmaLIGAND1, Sigma-LIGAND-1, Sigmareceptor, σ-LIGAND-1

Compound Identifiers

PubChem CID

9890959