Siegeskaurolic acid

SKU: orb1681684

Description

Siegeskaurolic acid is a bioactive small molecule that demonstrates anti-inflammatory and antinociceptive properties. Its mechanism involves the suppression of NF-κB signaling, leading to reduced iNOS and COX-2 expression in macrophages. This activity supports its use in research models for inflammation and pain, both in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 52645-97-3
• MW: 320.47
• Purity: 98.00% (May vary between batches)
• Formula: C₂₀H₃₂O₃
• SMILES: C[C@]12[C@]3([C@]4(C[C@@](CC3)([C@H](CO)C4)[H])CC[C@@]1([C@@](C(O)=O)(C)CCC2)[H])[H]
• Target: NOS,Prostaglandin Receptor,NO Synthase,COX,TNF,NF-κB

Bioactivity

• In Vivo:
  Pretreatment with Siegeskaurolic acid (20 or 30 mg/kg/day, p.o.) exhibited anti-inflammatory and antinociceptive effects in acetic acid-induced mouse models.
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• In Vitro:
  Siegeskaurolic acid inhibits iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB inactivation.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TNF-α, Siegeskaurolic acid, PGE, Prostaglandin Receptor, ProstaglandinReceptor, COX, NOSynthase, NOS, NF-κB, NFkB, NF-kB, NFκB, NO, NO Synthase, p65

Compound Identifiers

PubChem CID

44575990