SIAIS164018 hydrochloride

SKU: orb2279007

Description

SIAIS164018 hydrochloride is a potent PROTAC degrader of ALK and EGFR, with IC50 values of 2.5 nM for ALK and 6.6 nM for the ALK G1202R mutant. It demonstrates robust anti-cancer activity in vitro by inhibiting cell migration and invasion, inducing G1 phase arrest, and promoting apoptosis, outperforming brigatinib in these assays.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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MW	919.79
Formula	C₄₃H₄₉Cl₂N₁₀O₇P
Target	EGFR,Apoptosis,PROTACs,ALK

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

EGFR,Apoptosis,PROTACs,ALK

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