SIAIS164018 hydrochloride

SKU: orb2279007

Description

SIAIS164018 hydrochloride is a potent PROTAC degrader of ALK and EGFR, with IC50 values of 2.5 nM for ALK and 6.6 nM for the ALK G1202R mutant. It demonstrates robust anti-cancer activity in vitro by inhibiting cell migration and invasion, inducing G1 phase arrest, and promoting apoptosis, outperforming brigatinib in these assays.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 919.79
• Formula: C₄₃H₄₉Cl₂N₁₀O₇P
• Target: Apoptosis,PROTACs,ALK,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,PROTACs,ALK,EGFR