SI-W052

SKU: orb3027924

Description

SI-W052 is an orally active, brain-penetrant, and selective small molecule inhibitor that targets mTOR and TEX264. It activates autophagy by inhibiting mTOR phosphorylation, enhances TEX264 expression to promote endoplasmic reticulum renewal, and suppresses the release of LPS-induced inflammatory factors (TNF-α, IL-6). SI-W052 shows potential for research into neuroinflammation associated with Alzheimer's disease (AD).

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2572552-60-2
• MW: 434.89
• Formula: C₂₀H₁₉ClN₂O₅S
• SMILES: O=C(O)C1=CC(=C(Cl)C=C1NCC=2OC=CC2)S(=O)(=O)N(C)CC=3C=CC=CC3
• Target: Autophagy,Interleukin,mTOR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Autophagy,Interleukin,mTOR