SI-2

SKU: orb1699309

Description

SI-2 is a potent and selective small molecule inhibitor of the steroid receptor coactivator-3 (SRC-3/AIB1). It effectively degrades SRC-3 protein and suppresses its transcriptional activity, inducing selective apoptosis in breast cancer cells at low nanomolar concentrations while sparing normal cells. This compound is a valuable chemical probe for studying SRC-3 biology in cancer research, supporting both in vitro and in vivo experimental applications.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 223788-33-8
• MW: 265.31
• Purity: 98.40% (May vary between batches)
• Formula: C₁₅H₁₅N₅
• SMILES: CN1C=2C(N=C1NN=C(C)C3=CC=CC=N3)=CC=CC2
• Target: Src,Others,Apoptosis
• Solubility: DMSO:55 mg/mL (207.3 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EPH116, EPH-116, EPH 116, steroid receptor coactivator-3, SI 2, SI-2, SI2

Compound Identifiers

PubChem CID

85054622