SHY-855

SKU: orb3173501

Description

SHY-855 is a pan-RAS inhibitor that effectively blocks the binding of K-Ras protein and other members of the RAS small GTPase superfamily, with an IC50 value ranging from 0.3 to 5 μM. It efficiently inhibits the phosphorylation of downstream targets such as MEK, ERK1/2, and AKT. Additionally, SHY-855 prevents the formation of Ras-GTP active complexes. This compound can be utilized in research related to pancreatic cancer and non-small cell lung cancer.

Key Properties

• CAS Number: 2446485-15-8
• MW: 506.02
• Formula: C₂₆H₂₄ClN₅O₂S
• SMILES: ClC=1C(OC)=CC=CC1C=2SC3=NC(=NC(NCCOC)=C3C2C=4C=CC=CC4)C5=NC=CN5C
• Target: Ras,MEK,ERK,Akt

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras,MEK,ERK,Akt