SHP389

SKU: orb2695154

Description

SHP389 is a potent and selective allosteric SHP2 inhibitor, effectively suppressing SHP2 activity and downstream p-ERK signaling. It is a valuable research tool for investigating oncogenic pathways in cancers driven by RTK/RAS signaling, with utility in both cellular and animal model studies.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2235394-90-6
• MW: 484.98
• Purity: 98.24% (May vary between batches)
• Formula: C₂₃H₂₉ClN₈O₂
• SMILES: N[C@H]1C2(CCN(CC2)C3=NC=4C(C(=O)N3C)=C(NN4)C=5C(Cl)=C(NC6CC6)N=CC5)CO[C@H]1C
• Target: Phosphatase,ERK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.31 mM);DMSO:80 mg/mL (164.96 mM)

Bioactivity

• Target IC50:
  SHP2:36 nM
• In Vivo:
  SHP389 modulates MAPK signaling in vivo.
• In Vitro:
  SHP389 is an allosteric inhibitor of SHP2 with IC50 of 36 nM for SHP2. SHP389 showed high clearance in rat liver microsomes in vitro (Cl = 26.1 μL/min/mg, T1/2 = 53.2 min), large distribution volume (3.9 L/kg), terminal half-life of 2.7 h, and oral bioavailability of 2%.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SHP389, SHP-389, SHP 389

Compound Identifiers

PubChem CID

124147932