SHP2-IN-8

SKU: orb1688147

Description

SHP2-IN-8 is a potent, selective, and reversible allosteric inhibitor of SHP2 with an IC50 of 23 nM. It induces target thermal stabilization (ΔTm = 7.01°C) and demonstrates cellular activity by inhibiting AKT phosphorylation and promoting apoptosis in HeLa cells, useful for cancer signaling research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1801692-60-3
• MW: 398.35
• Formula: C₁₇H₂₁Cl₂N₅S
• SMILES: NC=1N=C(N2CCC(CN)(C)CC2)C=NC1SC3=C(Cl)C(Cl)=CC=C3
• Target: Apoptosis,Others,Phosphatase,Akt

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

118239405