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SHP2-IN-47

SKU: orb3211452

Description

SHP2-IN-47 is a potent and selective SHP2 inhibitor with an IC50 value of 0.80 μM. It exhibits strong inhibitory activity against SHP2E76K, with an IC50 of 0.37 μM. SHP2-IN-47 functionally inhibits the protein tyrosine phosphatase domain and reduces SHP2-mediated phosphorylation levels of AKT and ERK. It can induce apoptosis and inhibit the proliferation of cancer cells, making it a valuable compound for cancer research, including studies on acute myeloid leukemia.

Images & Validation

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SHP2-IN-47

Key Properties

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TargetApoptosis,Akt,Phosphatase,ERK

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Gene Symbol
Apoptosis,Akt,Phosphatase,ERK

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