SHP2-IN-44

SKU: orb3173212

Description

SHP2-IN-44 (Compound 26) is an allosteric, orally active inhibitor of SHP2, with an IC50 of 27 nM. It effectively inhibits ERK phosphorylation with an IC50 of 299 nM and exhibits no off-target hERG activity. SHP2-IN-44 shows broad-spectrum anticancer activity, including efficacy against juvenile myelomonocytic leukemia, neuroblastoma, and breast cancer. It is also useful for research in Noonan syndrome, LEOPARD syndrome, and cancer.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2818955-47-2
• MW: 471.98
• Formula: C₂₂H₂₃ClFN₇S
• SMILES: C(N)[C@]1([C@@]2([C@]1(CCN(C2)C3=NC(N)=C(SC=4C(Cl)=C(N)N=CC4)N=C3)[H])[H])C5=C(F)C=CC=C5
• Target: Phosphatase,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Phosphatase,ERK