SHP2-IN-23

SKU: orb2565295

Description

SHP2-IN-23 (compound 30) is a potent, orally bioavailable SHP2 inhibitor with an IC50 of 38 nM. It effectively blocks downstream ERK phosphorylation (IC50 = 5 nM) and demonstrates robust in vivo efficacy, making it a valuable chemical probe for cancer research, particularly in studying RTK and MAPK signaling pathways.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2415989-91-0
• MW: 491.01
• Formula: C₂₄H₂₃ClN₈S
• SMILES: N[C@H]1C2(CC=3C1=CC=CN3)CCN(CC2)C4=NC5=C(N=C4)N=C(SC=6C(Cl)=C(N)N=CC6)C=C5
• Target: Phosphatase,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

146485511