SHP2-IN-22

SKU: orb2278324

Description

SHP2-IN-22 is a potent allosteric SHP2 inhibitor with an IC50 of 17.7 nM. It effectively inhibits proliferation, migration, and invasion in KRAS-mutant MIA PaCa-2 pancreatic cancer cells in vitro, making it a valuable tool for studying oncogenic signaling in KRAS-driven cancers.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2802453-88-7
• MW: 497.38
• Formula: C₂₃H₂₂Cl₂N₈O
• SMILES: NC=1C(=NC=C(N1)N2CCN(C(NC3=CC(OC)=C(C#N)C=C3)=N)CC2)C4=C(Cl)C(Cl)=CC=C4
• Target: Others,Phosphatase,Ras,Kras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

169450675