SHP099

SKU: orb1304056

Description

SHP099 is a potent, selective, and orally bioavailable SHP2 inhibitor with cellular activity, demonstrating dose-dependent inhibition of downstream signaling and antitumor efficacy in xenograft models. It is widely used in cancer research to investigate SHP2's role in RAS/MAPK pathway-driven tumors through both in vitro and in vivo studies.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1801747-42-1
• MW: 352.26
• Purity: 99.48% (May vary between batches)
• Formula: C₁₆H₁₉Cl₂N₅
• SMILES: CC1(N)CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl
• Target: Phosphatase,ERK
• Solubility: DMSO:15.8 mg/mL (44.85 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.84 mM)

Bioactivity

• Target IC50:
  MV-4-11 cells:0.32 μM|SHP2E76K:2.896 μM|4T1 cells:119.3 μM|SHP2 (E69K):0.416 μM|ASPC1 cells:64.04 μM|pERK:0.250 μM|Capan-2 cells:15.67 μM|BXPC-3 cells:72.86 μM|BaF3 cells:19.86 μM|SHP2A72V:1.968 μM|SHP2:0.07 μM|SHP2 (D61Y):1.241 μM|TF-1 cell:1.73 μM
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Phosphatase, SHP-2, SHP-099, SHP099 free base, SHP099, SHP 099, PERK

Compound Identifiers

PubChem CID

118238298