SHMT2-IN-1

SKU: orb3173831

Description

SHMT2-IN-1 is a potent inhibitor of serine hydroxymethyltransferase 2 (SHMT2) with an IC50 of 1.21 μM and a KD of 10.6 μM. It binds to the folate binding site of SHMT2 and also inhibits SHMT1 with an IC50 of 1.83 μM. MT-44 can suppress the proliferation, migration, and invasion of cancer cells, inducing apoptosis and reactive oxygen species (ROS) production, leading to G2/M phase arrest. SHMT2-IN-1 is applicable in cancer research, including studies on esophageal cancer.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• Target: ROS,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROS,Apoptosis