SHMT-IN-2

SKU: orb1687640

Description

SHMT-IN-2 is a potent dual inhibitor of human serine hydroxymethyltransferase isoforms 1 and 2 (SHMT1/2). It demonstrates potent anti-proliferative activity against various human cancer cell lines in vitro, with particular sensitivity noted in B-cell lymphoma models, making it a valuable chemical probe for oncology research.

Key Properties

• CAS Number: 2102681-49-0
• MW: 431.45
• Purity: 99.79% (May vary between batches)
• Formula: C₂₂H₂₄F₃N₅O
• SMILES: CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)N1CCCC1
• Target: Others
• Solubility: DMSO:90 mg/mL (208.6 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.65 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SHMT1, SHMT2

Compound Identifiers

PubChem CID

134335070