Shionone

SKU: orb1222911

Description

Shionone is an effective inhibitor of human neutrophil elastase which may be used as a treatment for inflammatory lung diseases including H1N1 and SARS virus infections. Shiononeis a tetracyclic triterpenoid is the major triterpenoid component of Aster tataricus possessing a unique all six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure. is perhydrochrysene which is substituted by methyl groups at positions 1, 4bβ, 6aα, 8β, 10aβ and 12a positions, by a 4-methylpent-3-enyl group at the 8α position, and with an oxo group at position 2.

Key Properties

• CAS Number: 10376-48-4
• MW: 426.72
• Purity: >98% (HPLC)
• Formula: C₃₀H₅₀O
• SMILES: CC1C(=O)CCC2C1(CCC3C2(CCC4(C3(CCC(C4)(C)CCC=C(C)C)C)C)C)C
• Target: Others
• Solubility: In Vitro: Ethanol : 2 mg/mL (4.69 mM)

Bioactivity

• In Vivo:
  Shionone (orally administration; 80 mg/kg; 3 days; once daily) shows the trend of enhancing sputum secreting, but has no effect on ammonia-induced cough and reduces xylene-induced ear edema. Animal model: ICR male mice. Dosage: 80 mg/kg. Administration: Orally administration; 3 days; once daily. Result: Reduced the ear edema for 11.3% by use shionone.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Shionone | UNII-BT0AMD31UB

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Gene Symbol

Others