SGN-2FF

SKU: orb1309107

Description

SGN-2FF is a small molecule inhibitor of fucosyltransferase enzymes, exhibiting antitumor properties. It is utilized in cancer research to study the role of protein fucosylation in tumor progression, with applications in both in vitro cellular assays and in vivo animal models of oncology.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2089647-47-0
• MW: 166.15
• Purity: 99.63% (May vary between batches)
• Formula: C₆H₁₁FO₄
• SMILES: C[C@@H]1OC(O)[C@@H](F)[C@H](O)[C@@H]1O
• Target: Transferase,Others
• Solubility: DMSO:50 mg/mL (300.93 mM);H2O:35 mg/mL (210.65 mM)

Bioactivity

• In Vivo:
  In multiple mouse tumor models, SGN-2FF exhibits antitumor activity. SGN-2FF shows substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model.
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• In Vitro:
  SGN-2FF is a fucosylation inhibitor, SGN-2FF inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of fucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Fucosyltransferase, inhibit, SGN 2FF, SGN2FF, SGN-2FF

Compound Identifiers

PubChem CID

44544736