SGK1-IN-1

SKU: orb1708541

Description

SGK1-IN-1 (compound 14n) is a potent and selective inhibitor of Serum/Glucocorticoid Regulated Kinase 1, demonstrating IC50 values of 41 nM, 128 nM, and 310 nM against hSGK1, 2, and 3, respectively, at physiological ATP levels. This tool compound enables the investigation of SGK1 signaling in cancer biology and metabolic disorder research, supporting both in vitro and in vivo experimental models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 1279829-87-6
• MW: 418.83
• Purity: 97.44% (May vary between batches)
• Formula: C₁₇H₁₂ClFN₆O₂S
• SMILES: O=S(=O)(NC=1C=CC(=CC1)C2=NC=3NN=C(N)C3N=C2)C4=CC(Cl)=CC=C4F
• Target: SGK
• Solubility: 10% DMSO+90% Saline:2 mg/mL (4.78 mM);H2O:1.5 mg/mL (3.58 mM);DMSO:40 mg/mL (95.5 mM)

Bioactivity

• Target IC50:
  SGK1:1 nM
• In Vitro:
  Method: Kinase inhibition assays were conducted to evaluate the selectivity and activity of SGK1-IN-1 (14n) against SGK family members at different ATP concentrations. Additionally, its inhibitory effect on GSK3β phosphorylation was assessed in U2OS cells. Result: SGK1-IN-1 showed strong activity against hSGK1 (IC₅₀ = 1 nM), good activity against hSGK2, moderate activity against hSGK3 (IC₅₀ = 41 nM), and exhibited cellular activity with an IC₅₀ of 0.69 μM in U2OS cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SGK-1, SGK1IN1, SGK1-IN-1, SGK-1-IN-1, SGK1 IN 1

Compound Identifiers

PubChem CID

71506845