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SGI-1027

SKU: orb1227144

Description

SGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B; induces selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B in different cancer cell lines.

Images & Validation

Key Properties

CAS Number1020149-73-8
MW461.5178
Purity>98% (HPLC)
FormulaC27H23N7O
SMILESO=C(NC1=CC=C(NC2=NC(N)=NC(C)=C2)C=C1)C3=CC=C(NC4=CC=NC5=CC=CC=C45)C=C3
TargetDNMT
SolubilityDMSO: 27 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SGI1027 | SGI 1027

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Protocol Information

Available Sizes

Select a size below

5 mg
$ 100.00
10 mg
$ 170.00
25 mg
$ 270.00
50 mg
$ 500.00
100 mg
$ 770.00
500 mg
$ 1,680.00