SGC-CK2-1

SKU: orb1690816

Description

SGC-CK2-1 is a potent and selective casein kinase 2 (CK2) inhibitor. It has been shown to stimulate insulin production and secretion in pancreatic β-cells in vitro, supporting its use in diabetes and neurodegenerative disease research.

Research Area

Metabolism Research, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2470424-39-4
• MW: 375.43
• Purity: 99.41% (May vary between batches)
• Formula: C₂₀H₂₁N₇O
• SMILES: CCC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1C
• Target: Casein Kinase
• Solubility: DMSO:80 mg/mL (213.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.79 mM)

Bioactivity

• Target IC50:
  CK2α:16 nM (IC50)|CSNK2A1:4.2 nM|CSNK2A2:2.3 nM|DYRK2:3.7 μM|CK2α:36 nM (IC50)
• In Vitro:
  SGC-CK2-1 is a selective inhibitor with IC50 values of 2.3 nM and 4.2 nM for CSNK2A2 and CSNK2A1, respectively, and an IC50 value of 3.7 μM for DYRK2.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Casein Kinase, CaseinKinase, CK2, SGC CK2 1, SGCCK21, SGC-CK-2-1, SGC-CK2-1

Quick Database Links

Gene Symbol

Casein Kinase