SGC-CBP30

SKU: orb1300573

Description

SGC-CBP30 is a potent and selective small molecule inhibitor of the CREBBP and EP300 bromodomains, with IC50 values of 21 nM and 38 nM, respectively. It is a valuable chemical probe for epigenetic research, used in vitro to investigate the roles of these acetyl-lysine readers in gene regulation, cellular differentiation, and disease models.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1613695-14-9
• MW: 509.04
• Purity: >99.99% (May vary between batches)
• Formula: C₂₈H₃₃ClN₄O₃
• SMILES: COc1ccc(CCc2nc3cc(ccc3n2C[C@H](C)N2CCOCC2)-c2c(C)noc2C)cc1Cl
• Target: Histone Acetyltransferase,Epigenetic Reader Domain
• Solubility: DMSO:247.5 mg/mL (486.21 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.48 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:93 mg/mL (182.7 mM)

Bioactivity

• Target IC50:
  CREBBP:21 nM|EP300:38 nM
• In Vivo:
  SGC-CBP30 exhibits moderate cytotoxicity in U2OS and HeLa cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CREBBP, cells, BRD, ankylosing, anti-inflammatory, arthritis, Inhibitor, HAT, HATs, Histone Acetyltransferase, HistoneAcetyltransferase, EP300, Epigenetic Reader Domain, epigenetic, EpigeneticReaderDomain, inhibit, IL-17A, SGC-CBP30, SGC-CBP-30, SGCCBP30, SGC CBP30, psoriatic, spondylitis, Th17

Compound Identifiers

PubChem CID

72201027