SGC-AAK1-1

SKU: orb1309109

Description

SGC-AAK1-1 is a potent, selective chemical probe targeting AP2-associated kinase 1 (AAK1) with a Ki of 9 nM. This inhibitor is a valuable tool for investigating AAK1's role in clathrin-mediated endocytosis and neurological processes in both cellular and animal models.

Research Area

Neuroscience, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2247894-32-0
• MW: 427.52
• Purity: 99.68% (May vary between batches)
• Formula: C₂₁H₂₅N₅O₃S
• SMILES: CCN(CC)S(=O)(=O)Nc1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
• Target: AAK1,Wnt/beta-catenin,AAK1 (AP2 associated kinase 1)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.68 mM);DMSO:40 mg/mL (93.56 mM)

Bioactivity

• Target IC50:
  AAK:9 nM
• In Vitro:
  phosphorylation of AP2M1 (T156)significantly reduced by SGC-AAK1-1 (1.25 μM) and activates WNT-driven BAR activity compared in a dose-dependent manner in HT1080 cells. SGC-AAK1-1 blocks AAK1 kinase activity, resulting in increased β-catenin protein stability and β-catenin-dependent transcription.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMP2K, AP2associatedkinase1, AP2, AP2 associated kinase 1, associated, AAK1 (AP2 associated kinase 1), AAK1, AAK1(AP2associatedkinase1), AAKki, Inhibitor, kinase, inhibit, pathway, SGCAAK11, SGC-AAK-1-1, SGC-AAK1-1, SGC AAK1 1, Wnt

Compound Identifiers

PubChem CID

134812845