SG-55

SKU: orb3211209

Description

SG-55 is a selective, non-competitive, orally active inhibitor of AKR1C3, with an IC50 of 5 nM and a Ki of 10 nM. It has over 2000-fold higher selectivity for AKR1C3 compared to AKR1C1, AKR1C2, and AKR1C4 (>10 μM). SG-55 enhances the NADPH/NADP+ ratio, decreases the GSH/GSSG ratio, and induces DNA double-strand breaks. Additionally, SG-55 can overcome resistance to Osimertinib mediated by the EGFRC797S triple mutation in non-small cell lung cancer (NSCLC).

Key Properties

• Target: Reductase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Reductase