SFI003

SKU: orb1745156

Description

SFI003 is a novel small molecule inhibitor of SRSF3 that induces apoptosis in colorectal cancer cells by disrupting the SRSF3/DHCR24 axis and elevating reactive oxygen species (ROS). This compound is a valuable research tool for investigating CRC mechanisms and therapeutic strategies in both in vitro and in vivo models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2361332-90-1
• MW: 363.44
• Purity: 99.44% (May vary between batches)
• Formula: C₁₉H₁₇N₅OS
• SMILES: C(=N\NC1=NC(=CS1)C2=CC=C(OC)C=C2)(\C)/C=3NC=4C(N3)=CC=CC4
• Target: Apoptosis,ROS,Reactive Oxygen Species
• Solubility: DMSO:50 mg/mL (137.57 mM)

Bioactivity

• Target IC50:
  SW480 cells:48.67 µM|HCT116 cells:8.78 µM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ROS, apoptosis

Compound Identifiers

PubChem CID

141745171