SF-9-2

SKU: orb3136343

Description

SF-9-2 is a PD-L1/PD-1 binding inhibitor with an IC50 of 24.9 nM. It suppresses epithelial-mesenchymal transition, migration, invasion, and proliferation of SK-N-SH cells, while also inducing apoptosis and causing cell cycle arrest. SF-9-2 blocks PD-L1-induced growth of SK-N-SH cells via the MAPK signaling pathway. It restores GSK-3β activity and enhances PD-L1 degradation through the ubiquitin-proteasome pathway. In the SK-N-SH NOG mouse model, SF-9-2 inhibits tumor growth without notable toxicity. Additionally, SF-9-2 acts as an immune checkpoint inhibitor, blocking PD-L1 to restore T cell function and is applicable to neuroblastoma research.

Research Area

Cell Biology, Immunology & Inflammation, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3053768-78-5
• MW: 515.55
• Formula: C₃₀H₂₇F₂N₃O₃
• SMILES: N#CC1=CN=CC(=C1)COC2=CC(OCC3=CC=CC(C=4C=CC=CC4F)=C3CF)=CC=C2CNCCO
• Target: Bcl-2 Family,Cadherin,GSK-3,IFNAR,ERK,p38 MAPK,Apoptosis,Caspase,JNK,PD-1/PD-L1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Bcl-2 Family,Cadherin,GSK-3,IFNAR,ERK,p38 MAPK,Apoptosis,Caspase,JNK,PD-1/PD-L1