SEW​2871

SKU: orb1306226

Description

SEW 2871 is a potent and selective oral S1P1 receptor agonist (EC50=13.8 nM) that induces lymphocyte reduction and receptor internalization. It is utilized in research models for inflammation, liver fibrosis, Alzheimer's disease, and diabetes, where it modulates ERK, Akt, and Rac signaling pathways.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 256414-75-2
• MW: 440.36
• Purity: 99.96% (May vary between batches)
• Formula: C₂₀H₁₀F₆N₂OS
• SMILES: FC(F)(F)c1sc(cc1-c1ccccc1)-c1nc(no1)-c1cccc(c1)C(F)(F)F
• Target: ERK,LPL Receptor,S1P Receptor,Akt
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.27 mM);DMSO:8.8 mg/mL (19.98 mM)

Bioactivity

• Target IC50:
  S1P1:13.8 nM (EC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

colitis, Crohn's disease, diabetes, Akt, Alzheimer's disease, ERK, Extracellular signal regulated kinases, Inhibitor, inhibit, ischaemia-reperfusion injury, LX-2 cells, LPLReceptor, LPL, LPL Receptor, liver fibrosis, Lysophospholipid Receptor, orally active, S1P1, S1P Receptor, S1PReceptor, SEW?2871, SEW2871, SEW-2871, SEW​2871, SEW 2871, PKB, Protein kinase B

Compound Identifiers

PubChem CID

4077460