SET-12

SKU: orb3174511

Description

SET-12 is a highly active and selective antiparasitic agent against Leishmania amazonensis. It demonstrates outstanding activity against the promastigote form of the parasite, with an IC50 of 10.89 μM and a selectivity index (SI) of up to 12.1. Additionally, SET-12 is effective against intracellular amastigotes, with an IC50 of 3.81 μM and an SI that increases to 34.5. SET-12 also induces signs of apoptosis in the parasites, such as mitochondrial damage and the accumulation of reactive oxygen species (ROS).

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 2241572-39-2
• MW: 359.47
• Formula: C₂₁H₂₉NO₄
• SMILES: C([C@H]([C@@H](CCC1=CC=CC=C1)O)/C=C/CC)(=O)N2[C@@H](C(C)C)COC2=O
• Target: ROS,Parasite,Apoptosis,DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

ROS,Parasite,Apoptosis,DNA/RNA Synthesis