Sesamol

SKU: orb1303917

Description

Sesamol (1,3-Benzodioxol-5-ol) is a research compound shown to mitigate lung injury and inflammation in rat models by activating AMPK/Nrf2 pathways and inhibiting NF-κB/MAPK signaling. It also reduces melanogenesis in melan-a cells by downregulating MITF and tyrosinase activity, involving p38 and JNK phosphorylation. This makes it applicable for studying oxidative stress, inflammatory diseases, and skin pigmentation mechanisms in both in vivo and in vitro systems.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 533-31-3
• MW: 138.12
• Purity: >99.99% (May vary between batches)
• Formula: C₇H₆O₃
• SMILES: OC1=CC2=C(OCO2)C=C1
• Target: Apoptosis,AMPK
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate:Soluble;DMSO:70 mg/mL (506.81 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (72.4 mM)

Storage & Handling

• Storage: store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPK, Apoptosis, 1,3-Benzodioxol-5-ol, 3,4-Methylenedioxyphenol, Inhibitor, inhibit, Sesamol

Compound Identifiers

PubChem CID

68289