SERT/NET-IN-1

SKU: orb3211330

Description

SERT/NET-IN-1 is a SERT and NET inhibitor with blood-brain barrier permeability, exhibiting an IC50 of 11.2 nM for human SERT and 32.0 nM for human NET. It blocks 5-HT reuptake, enhancing serotonergic signaling, and also inhibits norepinephrine reuptake, boosting central noradrenergic transmission while suppressing the ejaculatory reflex. This compound extends ejaculatory latency, reduces ejaculation frequency, and maintains sexual function. SERT/NET-IN-1 shows metabolic stability across species' microsomes, has acceptable oral brain exposure in rats, and demonstrates good safety. It is applicable in research on premature ejaculation.

Key Properties

• Target: Serotonin Transporter,5-HT Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Serotonin Transporter,5-HT Receptor