Sertindole

SKU: orb1301425

Description

Sertindole (Lu 23-174) is an atypical antipsychotic research compound with high affinity for dopamine D2 and serotonin 5-HT2A/2C/1D receptors. It is utilized in preclinical in vitro and in vivo studies investigating neuropharmacology and receptor signaling mechanisms.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 106516-24-9
• MW: 440.94
• Purity: 99.92% (May vary between batches)
• Formula: C₂₄H₂₆ClFN₄O
• SMILES: Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2cc(Cl)ccc12
• Target: 5-HT Receptor,Autophagy,Adrenergic Receptor,Dopamine Receptor
• Solubility: DMSO:< 1 mg/mL (insoluble)

Bioactivity

• In Vivo:
  In vivo, sertindole (10 mg/kg) increases extracellular dopamine, acetylcholine (ACh), and glutamate levels in the medial prefrontal cortex in conscious rats.Sertindole (2.5 mg/kg) reverses ketamine-induced impairments in the extradimensional shift stage of the attentional set-shifting task (ASST) in rats.It reverses phencyclidine (PCP)-induced selective reversal learning deficits in rats and subchronic PCP-induced deficits in the novel object recognition task in mice.
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• Animal Research:
  Rats were treated acutely with vehicle or drugs, and extracellular levels of neurotransmitters were assessed by microdialysis in freely moving animals.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, anti-proliferative activity, antipsychotic activity, BGC-823, 5HTReceptor, 5-hydroxytryptamine Receptor, 5HT Receptor, 5-HT, 801-D, A172, A549, 5-HT Receptor, AGS, AdrenergicReceptor, Adrenergic Receptor, D2, Dopamine, Dopamine Receptor, DopamineReceptor, CCRF-CEM, Bel-7402, Beta Receptor, COLO205, HT-29, Inhibitor, HepG2, HCT-15, MCF-7, MCF-10A, inhibit, K562, Jurkat, Lu 23-174, NCI-H446, NCI-H460, NCI-H661, MKN45, T47D, SUM159, SW480, SW620, Serotonin Receptor, SGC-7901, Sertindole, U87-MG, U118-MG, U251

Compound Identifiers

PubChem CID

60149