Serotonin hydrochloride

SKU: orb1226127

Description

Serotonin hydrochloride is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.(In Vitro):Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki= 44 μM). Results show that addition of 100 μM of Serotonin hydrochloride decreases the reaction velocity of COMT.(In Vivo):Serotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p<0.001). A significant increase in colonic 5-HT content is observed in IL-13-/- mice receiving Serotonin hydrochloride compare to IL-13-/- receiving vehicle following induction of DSS colitis.

Research Area

Neuroscience

Images & Validation

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Key Properties

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CAS Number	153-98-0
MW	212.68
Purity	>98% (HPLC)
Formula	C₁₀H₁₂N₂O·HCl
SMILES	Cl.NCCC1=CNC2=C1C=C(O)C=C2
Target	5-HT Receptor
Solubility	Ethanol: 2 mg/mL (9.4 mM); Water: 43 mg/mL (202.18 mM); DMSO: 43 mg/mL (202.18 mM)

Bioactivity

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In Vivo

Serotonin hydrochloride produces robust hypersensitivity compared with saline-treated controls (p<0.001). A significant increase in colonic 5-HT content is observed in IL-13-/-mice receiving Serotonin hydrochloride compared with IL-13-/-receiving vehicle following induction of DSS colitis.

In Vitro

Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modulation the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki = 44 μM). Results show that addition of 100 μM of Serotonin hydrochloride decreases the reaction velocity of COMT.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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5-HT | 5-Hydroxytryptamine

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Gene Symbol

5-HT Receptor

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