Sennidin A

SKU: orb1684982

Description

Sennidin A is a hydroxyanthraquinone-derived compound that inhibits the NS3 helicase with an IC50 of 0.8 µM. This small molecule is a useful research tool for studying viral replication mechanisms in vitro, particularly in the context of flavivirus infections like dengue.

Research Area

Infectious Disease & Virology, Metabolism Research, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 641-12-3
• MW: 538.46
• Purity: 100.00% (May vary between batches)
• Formula: C₃₀H₁₈O₁₀
• SMILES: OC(c(cc1O)cc([C@H]([C@H](c2cccc(O)c22)c3cc(C(O)=O)cc(O)c3C2=O)c2c3c(O)ccc2)c1C3=O)=O
• Target: transporter|||HCV Protease|||PI3K|||Akt

Bioactivity

• In Vitro:
  Here, we exploited the avidity of the Sennidin A (SA) tracer and radioiodinated SA (131I-SA) to necrotic tumors in order to further empower TNT. We showed high uptake and prolonged retention of SA in necrotic tumors and a quick clearance in other non-targeted tissues including the liver. On SPECT-CT images, tumor mass appeared persistently as a hotspot. Based on the prominent targetability of 131I-SA to the tumor necrosis, we designed a combinational theragnostic modality. The vascular disrupting agent (VDA) combretastatin A4 phosphate (CA4P) was used to cause massive tumor necrosis, which formed the target of 131I-SA that subsequently killed the residual tumor cells by cross-fire irradiation of beta particles. Consequently, 131I-SA combined with CA4P significantly inhibited tumor growth, extended tumor doubling time and prolonged mean animal survival
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt, Glucose transporter, GLUT, Inhibitor, Hepatitis C virus, HCV Protease, HCVProtease, HCV, inhibit, PI3K, PKB, Sennidin A, Protein kinase B

Compound Identifiers

PubChem CID

92826