Seneciphylline

SKU: orb1297567

Description

Seneciphylline is a mutagenic and hepatotoxic pyrrolizidine alkaloid, shown to transfer into rat milk. It modulates key hepatic detoxification enzymes, inducing epoxide hydrolase and glutathione-S-transferase while suppressing cytochrome P-450. This compound is used in toxicology research to study metabolic activation, detoxification pathways, and chemical hepatotoxicity in vitro and in vivo.

Research Area

Metabolism Research

Key Properties

• CAS Number: 480-81-9
• MW: 333.38
• Purity: 99.53% (May vary between batches)
• Formula: C₁₈H₂₃NO₅
• SMILES: [H][C@]12CCN3CC=C(COC(=O)[C@](C)(O)C(=C)C\C(=C\C)C(=O)O1)[C@]23[H]
• Target: Cytochromes P450,GST
• Solubility: DMSO:3.34 mg/mL (10.02 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Gutathione S-transferase, GST, GSTs, Glutathione transferases, epoxide, hydrase, CYPs, cytochrome, Cytochrome P450, alkaloid, P-450, P450, pyrrolizidine, Seneciphylline, Toxic

Compound Identifiers

PubChem CID

5281750