Senecionine

SKU: orb1296142

Description

Cytidine 5'-triphosphate disodium salt is an endogenous metabolite that acts as an agonist for certain cation-permeable ligand-gated ion channels. It is utilized in biochemical research to study nucleotide signaling, receptor function, and cellular physiology in both in vitro and ex vivo experimental models.

Key Properties

• CAS Number: 130-01-8
• MW: 335.39
• Purity: 99.96% (May vary between batches)
• Formula: C₁₈H₂₅NO₅
• SMILES: C\C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23
• Target: Others
• Solubility: DMSO:1.68 mg/mL (5.01 mM);Ethanol:1 mg/mL (2.98 mM)

Bioactivity

• In Vivo:
  Senecionine fails to stimulate epoxide hydrase, it diminishes the activity of glutathione-s-transferase, aminopyrine demethylase and AHH . Twice-weekly injections of senecionine, beginning on Day 12 or later, results in premature deliveries in three of seven rats, and the pups from all litters are stillborn or die shortly after birth .
• In Vitro:
  The cytotoxicity was greater in the absence of extracellular Ca2+ than in its presence, suggesting that alterations in intracellular Ca2+ distribution, and not an influx of extracellular Ca2+, were responsible for the Senecionine-induced hepatotoxicity .
• Animal Research:
  Swiss albino rats weighing 155-175 g are incubated for 3 consecutive days with seneciphylline and senecionine at a daily dose of 40 or 80 mg/kg body wt. Control animals received normal saline only. The animals are killed 24 h after the last dose. The livers are removed, weighed and then homogenized in 1.15% KCI, 0.02 HEPES (pH 7.4) .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Aureine, Senecionan-11,16-dione, 12-hydroxy-, Senecionin, Senecionine

Compound Identifiers

PubChem CID

5280906