Sematilide hydrochloride

SKU: orb1304043

Description

Sematilide hydrochloride is a class III antiarrhythmic agent that selectively blocks the rapid delayed rectifier potassium current (IKr). This action prolongs the cardiac action potential duration and effective refractory period, making it a useful research tool for studying arrhythmia mechanisms in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 101526-62-9
• MW: 349.87
• Purity: 99.41% (May vary between batches)
• Formula: C₁₄H₂₄ClN₃O₃S
• SMILES: Cl.CCN(CC)CCNC(=O)c1ccc(NS(C)(=O)=O)cc1
• Target: Potassium Channel
• Solubility: DMSO:55 mg/mL (157.2 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.86 mM)

Bioactivity

• Target IC50:
  K+ current:25 μM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, IKr, K+ current (IKr), inhibit, KcsA, current, CK1752, CK-1752, CK-1752A, CK 1752, channel, antiarrhythmic, blocker, Sematilide, Sematilide HCl, Sematilide hydrochloride, Sematilide Hydrochloride, Potassium Channel, PotassiumChannel

Compound Identifiers

PubChem CID

58504