Semaglutide

SKU: orb1306844

Description

Semaglutide is a potent GLP-1 receptor agonist with an EC50 of 6.2 pM in human receptor assays. It is widely used in research for studying metabolic diseases, including diabetes and obesity, in both in vitro cellular models and in vivo animal studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 910463-68-2
• MW: 4114
• Purity: 99.78% (May vary between batches)
• Formula: C₁₈₇H₂₉₁N₄₅O₅₉
• SMILES: CC[C@@H]([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC(C(C)(NC([C@@H](N)CC1=CN=CN1)=O)C)=O)CCC(O)=O)=O)=O)[C@H](O)C)=O)CC2=CC=CC=C2)=O)[C@H](O)C)=O)CO)=O)CC(O)=O)=O)C(C)C)=O)CO)=O)CO)=O)CC3=CC=C(O)C=C3)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)C)=O)C)=O)CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@@H](NC(CCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)=O)=O)=O)CCC(O)=O)=O)CC4=CC=CC=C4)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CC(C)C)=O)CC5=CNC6=CC=CC=C65)=O)C)=O)C
• Target: Autophagy,Glucagon Receptor,Apoptosis,IGF-1R,p38 MAPK,Bcl-2 Family
• Solubility: H2O:insoluble;0.1 M HCl:1.25 mg/mL (0.3 mM);H2O:10 mg/mL (2.43 mM);DMSO:50 mg/mL (12.15 mM);H2O:5 mg/mL (1.22 mM)

Bioactivity

• Target IC50:
  GLP1 receptor:6.2 pM (EC50)|albumin:27 µM

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Semaglutide, Inhibitor, inhibit, Glucagon Receptor, GlucagonReceptor, GLP-1, GCGR

Compound Identifiers

PubChem CID

56843331