Selinexor HCl

SKU: orb3211559

Description

Selinexor HCl (1393477-72-9 free base) is an oral selective XPO1 (XPO1/CRM1) inhibitor that induces cell cycle arrest and apoptosis in tumor cells by blocking the transport of tumor suppressor proteins from the nucleus to the cytoplasm, thereby promoting their accumulation within the nucleus. Selinexor has been studied for the treatment of malignant tumors such as multiple myeloma.

Key Properties

• MW: 479.77
• Purity: 99.90% (May vary between batches)
• Formula: C₁₇H₁₂ClF₆N₇O
• SMILES: O=C(/C=C\N1N=C(N=C1)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)NNC3=NC=CN=C3.Cl
• Target: CRM1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CRM1