Selegiline hydrochloride

SKU: orb1221230

Description

Selegiline hydrochloride is a selective reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM). Monoamine oxidase (MAO) inhibitors have utility in ameliorating a variety of neurological conditions including depression.(In Vitro):Selegiline (1 nM-1 μM) hydrochloride inhibits recombinant human MAO-B in a concentration-dependent manner.Selegiline (10 mM) hydrochloride increases the efflux of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) from the rat hypothalamus in vitro. Selegiline hydrochloride inhibits the efflux of dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) in a dose-dependent manner.(In Vivo):Selegiline (1 mg/kg; i.p. daily for 24 days) hydrochloride reduces Cocaine self-administration of mice and does not affect Cocaine-caused body weight loss. Selegiline hydrochloride reduces 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in frontal cortex.

Key Properties

• CAS Number: 14611-52-0
• MW: 223.74
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₈ClN
• SMILES: Cl.C[C@H](Cc1ccccc1)N(C)CC#C
• Target: MAO
• Solubility: DMSO: 30 mg/mL;Water: 20 mg/mL;Ethanol: 30 mg/mL

Bioactivity

• In Vivo:
  Selegiline (1 mg/kg; i.p. daily for 24 days) hydrochloride reduces Cocaine self-administration of mice and does not affect Cocaine-caused body weight loss. Selegiline hydrochloride reduces 3, 4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in frontal cortex. Animal model: Male C57BL/6J mice (20-22 g). Dosage: 1 mg/kg. Administration: i.p. daily for 24 days. Result: Single injection did not acutely affect mouse locomotor activity. 14 consecutive days administration did not affect food reward. Reduced Cocaine self-administration, and reduced DOPAC and 5-HIAA concentrations in frontal cortex.
• In Vitro:
  Selegiline (1 nM-1 μM) hydrochloride inhibits recombinant human MAO-B in a concentration-dependent manner. Selegiline (10 mM) hydrochloride increases the efflux of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) from the rat hypothalamus in vitro. Selegiline hydrochloride inhibits the efflux of dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) in a dose-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

R(-)-Deprenyl hydrochloride

Quick Database Links

Gene Symbol

MAO