Selamectin

SKU: orb1222507

Description

Selamectin is a topical parasiticide and anthelminthic used on dogs and cats. It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats.(In Vitro):The transport of radiolabelled Selamectin through Caco-2 monolayers shows that Selamectin is P-glycoprotein (P-gp) substrates with a secretory/absorptive ratio of 4.7. Selamectin inhibits the efflux of Rh-123 from peripheral blood lymphocytes (PBL) and the concentration of inhibition is similar to that of Verapamil.(In Vivo):A single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae.

Key Properties

• CAS Number: 220119-17-5
• MW: 769.96
• Purity: >98% (HPLC)
• Formula: C₄₃H₆₃NO₁₁
• SMILES: C/C/1=C\C[C@@H]2C[C@H](OC(=O)[C@H]3[C@@]4(/C(=C/C=C/[C@@H]([C@@H]1O[C@H]1C[C@H](OC)[C@@H](O)[C@H](C)O1)C)/CO[C@@H]4/C(=N\O)/C(=C3)C)O)C[C@]1(CC[C@H](C)[C@@H](C3CCCCC3)O1)O2
• Target: Caspase
• Solubility: DMSO : 100 mg/mL 129.88 mM

Bioactivity

• In Vivo:
  A single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae.
• In Vitro:
  The transport of radiolabelled Selamectin through Caco-2 monolayers shows that Selamectin is P-glycoprotein (P-gp) substrates with a secretory/absorptive ratio of 4.7. Selamectin inhibits the efflux of Rh-123 from peripheral blood lymphocytes (PBL) and the concentration of inhibition is similar to that of Verapamil.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Selamectin | Revolution | Stronghold

Quick Database Links

Gene Symbol

Caspase