SEL120-34A

SKU: orb1710104

Description

SEL120-34A is a potent, ATP-competitive inhibitor selective for CDK8, demonstrating antitumor activity. It shows high potency against CDK8/CycC and CDK19/CycC with significantly lower activity against CDK9. This compound is a valuable research tool for studying transcriptional regulation in oncology, with utility in both cellular and in vivo cancer models.

Research Area

Cell Biology

Key Properties

• CAS Number: 1609522-33-9
• MW: 414.14
• Purity: 99.70% (May vary between batches)
• Formula: C₁₅H₁₈Br₂N₄
• SMILES: CC1=C2C=3N(C(=N2)N4CCNCC4)CCCC3C(Br)=C1Br
• Target: CDK
• Solubility: DMSO:4.15 mg/mL (10.02 mM);H2O:< 0.65 mg/mL (1.56mM)（insoluble)

Bioactivity

• Target IC50:
  CDK9-CyclinT:1070 nM|CDK19-CyclinA:10.4 nM|CDK8-CyclinC:4.4 nM
• In Vivo:
  SEL120-34A (30 mg/kg and 60 mg/kg; p.o.) inhibits the growth of tumors in mice bearing MV4-11 cancer cells. SEL120-34A (30 mg/kg; p.o.) arrests the growth of KG-1-derived tumors.
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• In Vitro:
  SEL120-34A shows no obvious inhibition on CDK1, 2, 4, 6, 5, 7. SEL120-34A weakly suppresses CDK9 with an IC50 of 1070 nM. SEL120-34A is active against a panel of AML cell lines including KG-1, SKNO-1, HEL-60, MOLM-16, OciAML-2, MV-4-11, MOLM-6 and OciAML-3 cells with GI50<1 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDK9/cycT, CDK8/CycC, CDK19/CycC, SEL12034A, SEL-120-34A, SEL120-34A, SEL120 34A

Compound Identifiers

PubChem CID

73776233