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sEH inhibitor-19

SKU: orb2945627

Description

sEH inhibitor-19 (Compound (R)-14i) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 1.2 nM. This compound suppresses the expression of TNF-α and IL-6 and exhibits anti-inflammatory effects in mouse models of acute pancreatitis and Carrageenan-induced edema.

Images & Validation

Key Properties

MW527.535
FormulaC28H28F3N3O4
SMILESCOC1=C(C=C2[C@H]3CC4=C(CN3CCC2=C1)C=C(C=C4)NC(=O)NCC5=CC=C(C=C5)OC(F)(F)F)OC
TargetInterleukin,Epoxide Hydrolase,TNF

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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sEH inhibitor-19 (orb2945627)

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