sEH inhibitor-19

SKU: orb2945627

Description

sEH inhibitor-19 ((R)-14i) is a potent, orally bioavailable soluble epoxide hydrolase inhibitor (IC50 = 1.2 nM). It demonstrates anti-inflammatory activity by reducing TNF-α and IL-6 expression, validated in models of acute pancreatitis and Carrageenan-induced paw edema.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3107483-12-2
• MW: 527.535
• Formula: C₂₈H₂₈F₃N₃O₄
• SMILES: COC1=C(C=C2[C@H]3CC4=C(CN3CCC2=C1)C=C(C=C4)NC(=O)NCC5=CC=C(C=C5)OC(F)(F)F)OC
• Target: Interleukin,Epoxide Hydrolase,TNF

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676998