Sedanolide

SKU: orb1301513

Description

Sedanolide

Research Area

Cell Biology

Key Properties

• CAS Number: 6415-59-4
• MW: 194.27
• Purity: ≥95% (May vary between batches)
• Formula: C₁₂H₁₈O₂
• SMILES: CCCCC1OC(=O)C2=CCCCC12
• Target: Autophagy
• Solubility: DMSO:9 mg/mL (46.33 mM)

Bioactivity

• In Vitro:
  Sedanolide suppressed J5 cell viability by inducing autophagy. Phosphoinositide 3-kinase (PI3K)-I, mammalian target of rapamycin (mTOR) and Akt protein levels decreased, whereas PI3K-III, LC3-II and Beclin-1 protein levels increased following Sedanolide treatment in J5 cells. In addition, Sedanolide treatment upregulated nuclear p53 and damage-regulated autophagy modulator (DRAM) and downregulated cytosolic p53 and Tp53-induced glycolysis and apoptosis regulator (TIGAR) expression in J5 cells. Furthermore, the cytosolic phosphorylation of inhibitor of kappa B (IκB) and nuclear p65 and the DNA-binding activity of NF-κB increased after Sedanolide treatment. These results suggest that Sedanolide induces J5 cell autophagy by regulating PI3K, p53 and NF-κB autophagy-associated signaling pathways in J5 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sedanolide, Autophagy, inhibit, Inhibitor

Compound Identifiers

PubChem CID

5018391

Sang A Kwak 1, Jane J Lee 1, Ju Hong Park 2, Nami Joo 1 Phytochemical Profiling and Anti-Inflammatory Effects of Aerial and Underground Parts of Apium graveolens var. rapaceum (Celeriac): Potential Health Benefits of Discarded Aerial Parts Food Sci Nutr ., (2025)

PubMed: 41049417