(-)-Securinine

SKU: orb1303358

Description

Securinine is a plant-derived alkaloid that acts as a GABAA receptor antagonist. It is used in neuroscience research to study inhibitory neurotransmission and has been applied in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 5610-40-2
• MW: 217.26
• Purity: 99.87% (May vary between batches)
• Formula: C₁₃H₁₅NO₂
• SMILES: [H][C@]12C[C@@]3(OC(=O)C=C3C=C1)[C@@]1([H])CCCCN21
• Target: GABA Receptor
• Solubility: DMSO:2 mg/mL (9.21 mM)

Bioactivity

• In Vivo:
  In the tumor model, treatment with (-)-Securinine markedly inhibits tumor growth, suggesting its potential as an Acute Myeloid Leukemia (AML) treatment. Mice treated with (-)-Securinine (n=5 mice, bilateral tumors) show tumors that are, on average, over 75% smaller than those in vehicle-treated mice at the conclusion of the study.
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• In Vitro:
  (-)-Securinine significantly inhibits HeLa cells growth with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

()Securinine, (-)-Securinine, inhibit, Inhibitor, GABAReceptor, GABAA, GABA Receptor, Gamma-aminobutyric acid Receptor, Securinine, γ-Aminobutyric acid Receptor

Compound Identifiers

PubChem CID

442872