γ-Secretase-IN-2

SKU: orb2564583

Description

γ-secretase-IN-2 (Compound 36) is a potent and selective γ-secretase inhibitor with an IC50 of 0.07 nM. This small molecule is a valuable research tool for studying Notch signaling and amyloid precursor protein (APP) processing in both cellular and animal models of Alzheimer's disease and oncology.

Research Area

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 564462-36-8
• MW: 543.54
• Formula: C₃₁H₂₄F₃N₃O₃
• SMILES: N(C([C@@H]([C@@H](CO)C1=CC(F)=C(F)C=C1)C2=CC=C(F)C=C2)=O)[C@H]3N=C(C=4C(NC3=O)=CC=CC4)C5=CC=CC=C5
• Target: Gamma-secretase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

9959057