Seclidemstat

SKU: orb1302785

Description

Seclidemstat (SP-2577) is a potent and selective LSD1 inhibitor, demonstrating a mean IC50 of 127 nM. This small molecule is utilized in research areas such as oncology, notably for investigating its effects in preclinical models of Ewing sarcoma and other cancers, both in vitro and in vivo.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1423715-37-0
• MW: 450.94
• Purity: 99.76% (May vary between batches)
• Formula: C₂₀H₂₃ClN₄O₄S
• SMILES: CN1CCN(CC1)S(=O)(=O)c1cccc(c1)C(=O)N\N=C(/C)c1cc(Cl)ccc1O
• Target: Histone Demethylase
• Solubility: H2O:< 0.1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.87 mM);DMSO:100 mg/mL (221.76 mM)

Bioactivity

• Target IC50:
  LSD1:127 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SP 2577, SP2577, SP-2577, Sarcoma, SWI/SNF, reversible, replication, Seclidemstat, Inhibitor, inhibit, immunity, LSD1, Histone Demethylase, HistoneDemethylase, Ewing, antitumor, complex, DNA

Compound Identifiers

PubChem CID

135565033