Se-Aspirin

SKU: orb2281205

Description

Se-Aspirin (Se-NSAID-8) is a gastroprotective anticancer agent that suppresses NF-ĸB signaling and its downstream anti-apoptotic targets, leading to cell cycle arrest and apoptosis. It has demonstrated research utility in accelerating ulcer healing and in studies of pancreatic and colorectal cancer, both in vitro and in vivo.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1850293-95-6
• MW: 311.2
• Purity: 98.07% (May vary between batches)
• Formula: C₁₂H₁₂N₂O₃Se
• SMILES: N#C[Se]CCNC(=O)C=1C=CC=CC1OC(=O)C
• Target: Apoptosis,Bcl-2 Family,NF-κB

Bioactivity

• In Vivo:
  Aspirin (5-150 mg/kg, PO, once) displays significant antipyretic activity in adult yeast-fever male rats.
• In Vitro:
  Aspirin inhibits COX-1 and COX-2 in human articular chondrocytes with IC50 values ​​of 3.57 μM and 29.3 μM, respectively; Aspirin acetylates serine 530 of COX-1, thereby blocking the synthesis of thromboxane A in platelets and reducing platelet aggregation; Aspirin inhibits COX-2 protein expression by interfering with the binding of CCAAT/enhancer protein beta (C/EBPbeta) to its homologous sites on the COX-2 promoter/enhancer; Aspirin inhibits NF-κB-dependent transcription from the lgκ enhancer and long terminal repeat (LTR) in human immunodeficiency virus (HIV)-transfected T cells; Aspirin inhibits mitochondrial cytochrome c release, activation of p38 MAP kinase, and activation of the ceramide pathway.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Se-NSAID-8, Se Aspirin, SeAspirin, Mcl-1, Apoptosis, Bcl-xL

Compound Identifiers

PubChem CID

91758292